Physical Sciences Oncology Centers (PS-OC)

Physical Sciences Oncology Centers (PS-OC)

David K.A. Mordecai, principal scientist/lead investigator of RiskEcon® Lab, and Visiting Scholar at Courant Institute of Mathematical Sciences, was invited to make a presentation to the Physical Sciences Oncology Center (PS-OC) at Princeton University on January 29th, 2014. Dr. Mordecai and his collaborator were subsequently invited to further present related research to the PS-OC Steering Committee on March 19th, 2014.

Both presentations, involving the evolving metabolic heterogeneity of a tumor cell population as an economic phenomenon, are related to joint work with Andrew E. Sundstrom, who had been awarded his Ph.D. in computational biology at NYU Courant Institute of Mathematical Sciences. Dr. Sundstrom’s dissertation focused upon how hypoxia arises in heterogeneous and spatially complex tumor cell populations1, and he was employed (during 2013-2014) as a Senior Research Scientist affiliated with RiskEcon® Lab at Courant Institute of Mathematical Sciences.

The PS-OC is a collaborative network of twelve leading US research institutions to which the National Cancer Institute (NCI) has awarded cooperative agreements. The participating universities include Cornell, Johns Hopkins, MIT, Princeton and Stanford.

The January 29th, 2014 presentation:

“Spatial Niche Tournaments: Implications of Economic Tradeoffs in the Productivity Underlying Cancer Cell Metabolism”

The March 19th, 2014 presentation:

“Spatial Niche Strategies: The Roles of Economic Production and Exchange in Cancer Cell Metabolomics”

 

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  1. Note: Dr. Sundstrom’s dissertation coupled simulation, histological image characterization, formal verification, and adaptive high-dimensional spatial mapping, in a computational modeling framework to test certain aspects in silico, related to the inverse problem regarding initial conditions and model parameter values associated with local regions of tumor cell hypoxia.

 

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